Phosphoramidite Derivatives

Phosphoramidite derivatives are fundamental building blocks, particularly used in DNA and RNA synthesis.

• Structural Features: Contain a 3′-OH protecting group and a phosphoramidite functional group; they are core reagents in solid-phase DNA synthesis.
• Performance: High coupling efficiency, low byproduct formation, and controlled chain elongation.
• Applications:
  • Oligonucleotide synthesis
  • Production of chemically modified DNA/RNA
  • Synthesis of fluorescent- or probe-labeled nucleotides
•  Advantages: High purity, reproducible synthesis performance, and broad modification options.